Effect of concommitant Helicobacter pylori infection in patients with Giardiasis lamblia in Egypt

Giardiasis is one of the most common enteroprotozoal diseases; its association with Helicobacter pylori is a common clinical finding. This work studied the impact of such association. Fifty giardiasis patients were classified into two groups according to the concomitant presence of H. pylori and ten normal healthy controls were also included. All patients were subjected to complete history taking, thorough clinical and stool examination, endoscopy, and biopsy of gastric and duodenal mucosa as well as histopatological examination. Results revealed significant upper gastrointestinal symptoms [epigastric pain and anorexia] in giardiasis patients with H. pylori. Also, endoscopic and histopathologic examination showed significant gastric lesions in this group of patients as compared to those suffering only G. lamblia

Impact of helicobacter pylori infection on circulating interleukin-1beta [IL-1BETA] in gastroduodenal disorders

Helicobacter pylori [H. pylori] infection in characterized by marked changes in cytokine production, resulting from the immune response to infection. The H. pylori-associated diseases present with manifestations varying from mild non-ulcer dyspepsia or peptic ulcer disease [PUD] to gastric cancer. Study the effect of H. pylori infection on circulating serum levels of IL-1beta in some gastroduodenal disorders. According to upper gastrointestinal [GI] tract symptoms, upper GI endoscopy [including gastric pH measurement, ultra-rapid urease test-for the diagnosis of H-pylori infection, and biopsy], and histo-pathological examination, 80 patient with gastroduodenal disorders [20 gastric ulcer, 20 duodenal ulcer, 10 gastritis, 10 duodenitis and 20 gastric cancer] were studied. In addition, 10 apparently healthy subjects served as a control group. Circulating serum IL-1beta levels were determined for all subjects, by ELISA. The majority of gastroduodenal disorders studied had evidence of H. pylori infection and significantly higher serum IL-1beta than control subjects, being more in gastric disorders [gastritis, cancer and ulcer]. Gastric pH was significantly higher in patients with gastric disorders [gastric cancer, gastric ulcer and gastritis]. IL-1beta correlates positively with H. pylori infection in patients with duodenal ulcer and gastric ulcer. Meanwhile, it correlates negatively with gastric pH, in patients with gastric ulcer. Gastric pH and serum IL-1beta are significantly higher in cancer patients than in non-cancer patients. On other hand, H. pylori infection is detected more significantly in non-cancer patients. The mean serum IL-1beta was found to be significantly higher in patients with positive H. pylori infection than in those negative for H. pylori infection. IL-1beta is in an important pro-inflammatory cytokine with profound effects. Its acid inhibitory properties uniquely qualify it as a major player in the host's response to H. pylori infection and the diseases associated with it

Impact of coinfection with Schistosma mansoni on Helicobacter pylori induced disease

The impact of concomitant S. mansoni infection on H. pylori induced gastritis was studied in twenty patients infected exclusively with H. pylori. The patients were compared with twenty patients coinfected with the bacteria and S. mansoni and twelve patients with schistosomiasis alone. All patients were subjected to clinical, parasitological, endoscopic and histopathological studies. In addition, serum malondialdehyde level [MDA], as an indicator of lipid peroxidation was measured. The results of revealed that severe gastritis was significantly more common in the patients infected exclusively with H. pylori. Serum MDA was significantly higher in this group compared to the other groups. The results were discussed